Description
Product Characteristics:
The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]
Subcellular location: Cytoplasm
Synonyms: Superoxide Dismutase 1, ALS 1, ALS, ALS1, Amyotrophic lateral sclerosis 1 adult, Amyotrophic lateral sclerosis 1, Cu/Zn SOD, Cu/Zn superoxide dismutase, Homodimer, Indophenoloxidase A, IPOA, Mn superoxide dismutase, SOD 1, SOD, SOD soluble, SOD1, SOD2, SODC, Soluble indophenoloxidase A, Superoxide dismutase 1, Superoxide dismutase 1 soluble, Superoxide dismutase Cu Zn, Superoxide dismutase cystolic, SODC_HUMAN, Superoxide dismutase [Cu-Zn], hSod1, Ipo1, SODC, Ipo-1, Sod-1, CuZnSOD, Cu/Zn-SOD, MGC107553, B430204E11Rik, superoxide-dimutase-1.
Target Information: The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]